The Technology
Delphi·MDTM probes brain network response through non-invasive, radiation free, focused magnetic stimulation.
Neuronal response is automatically analyzed providing physiological measures of brain function in targeted brain networks.
Focused magnetic stimulation technology enables direct, safe, probing to specific brain areas, providing, for the first time, clinical measures of neuronal connectivity, reactivity and plasticity.
Active
Ping: a magnetic pulse over the subject’s head triggers the brain’s networks
Objective
Neuronal signal
processing
Real-Time
Automated mapping of cerebral processing activity
Insight
Generate clinically
actionable insights
Brain Network Physiological Measures
Delphi·MD directly measures basic neuronal network features
of connectivity, excitability, and plasticity.
Delphi·MD probes specific brain networks utilizing focused magnetic stimulation. These magnetically induced neuronal responses are well established signature waveforms that disperse in the brain in specific timing and intensities1.
Direct evaluation of electrical brain response provides measures of connectivity, excitability and plasticity which are the most fundamental features of neuronal network. These electrophysiological measures have been used in brain network science to quantify and evaluate brain network function and health for the past few decades2. Recent advances have enabled the scaling of this technology to the clinically accessible and safe Delphi·MD technology.
An unhealthy brain network displays inconsistent measures corresponding to specific probed brain areas and networks, thus aiding the physician in detection and diagnosis of neurological diseases.
1. Rossini PM, Burke D, Chen R, et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee. Clin Neurophysiol. Jun 2015;126(6):1071-107. doi:10.1016/j.clinph.2015.02.001
2. Tremblay S, Rogasch NC, Premoli I, et al. Clinical utility and prospective of TMS-EEG. Clin Neurophysiol. May 2019;130(5):802-844. doi:10.1016/j.clinph.2019.01.001
Publications
Delphi·MD in stroke and TBI
Evaluation of White Matter Integrity Utilizing the Delphi·MD System. Front Neurosci. 2020 Dec 21;14:589107.
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Delphi·MD for Detection of Healthy VS Unhealthy Brain Ageing
Introducing a Novel Approach for Evaluation & Monitoring of Brain Health Across Life Span Using Direct Non-invasive Brain Network Electrophysiology. Front Ageing Neurosci. 2019 Sep 9;11:248.
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Delphi·MD in Parkinson’s Disease
A multimodal approach using TMS and EEG reveals neurophysiological changes in Parkinson's disease, Parkinsonism & Related Disorders, Parkinsonism related dis. 2021 Jun 18 ; 89:28;
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Delphi·MD as Early dementia \Alzheimer’s Biomarker
Brain Network Integrity Changes in Subjective Cognitive Decline,
a Possible Physiological Biomarker of Dementia Journal: Fronti Neurology. 2021 July
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